Prof. Nils Metzler Nolte, Ruhr-Universität Bochum, Germany
Prof. Heinz-Bernhard Kraatz, University of Toronto, Scarborough, Canada
Prof. Takashi Hayashi, Osaka University, Japan
Biochemistry, Organometallic Chemistry, Medicinal Chemistry, Supramolecular Chemistry, Bioimaging
Recently, the research field of bioorganometallic chemistry, which is a hybrid area between biology and organometallic chemistry, has attracted great attention and undergone rapid development. Conjugation of organometallic compounds with biomolecules such as nucleobases, amino acids, peptides, and proteins is envisioned to provide novel bioorganometallic systems depending on both functional properties. In these bioorganometallic conjugates, the organometallic group can serve as a molecular scaffold, a redox-active site, a sensitive probe, a chromophore, a biological marker, a catalytic active site, etc. A great deal of effort has been devoted to designing bioorganometallic conjugates by the introduction of organometallic compounds into biomolecules. For example, a conjugation of organometallic ferrocene scaffold as a central reverse-turn unit with dipeptide chains has been demonstrated to induce antiparallel -sheet-like, type II -turn-like, and -turn-like structures depending on the chirality and sequence of amino acids. Artificial B12 derivatives and hybrid systems have been designed to perform bio-inspired catalytic reactions. A variety of bioorganometallic compounds have been demonstrated to show biological activities. The luminescent bioorganometallic complexes have been utilized as biomolecular and cellular probes. These bioorganometallic chemistry will provide a fundamental basis for protein folding, the design of drug candidates, artificial catalysts, and biomaterials. The aim of this session is to bring together researchers from around world working in this field to present their results, form new collaborations, and discuss the future prospects of bioorganometallic chemistry.